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production in
trinitrobenzene sulphonic acid induced colitis
C K Ameho
a Department of Nutrition, University of the Ryukyus,
Nishihara, Okinawa 903-01, Japan, b Department of Bacteriology, c Department of Adult Health, d First Department of Pathology, University of the
Ryukyus, e Department of Surgery, St Louis Medical Center, St Louis,
USA, f Daidochuo Hospital, Naha, Okinawa,
Japan, g Department of Nutrition, Kumamoto
Prefectural University, Kumamoto, Japan, h Department of Nutrition, Facultyof Medicine,
University of Tokushima, 3 Kuramoto, Tokushima 770, Japan
Correspondence to: Professor S
Yamamoto. Accepted for publication 25 March 1997 Background Keywords:
glutamine;
trinitrobenzene sulphonic acid;
inflammatory bowel disease;
rats;
interleukin 8;
tumour necrosis factor
It is well established that glutamine
supplemented elemental diets result in less severe intestinal damage in
experimental colitis. However, few studies have examined the mode of
action of glutamine in reducing intestinal damage.
AimsTo examine the effects of glutamine
supplemented elemental diets on the potent inflammatory cytokines
interleukin 8 (IL-8) and tumour necrosis factor 
(TNF-) in
trinitrobenzene sulphonic acid (TNBS) induced colitis which presents
with both acute and chronic features of ulcerative colitis.
MethodsSprague-Dawley rats were randomised into
three dietary groups and fed 20% casein (controls), or 20% casein
supplemented with either 2% glutamine (2% Gln) or 4% glutamine (4%
Gln). After two weeks they received intracolonic TNBS to induce
colitis.
ResultsBoth Gln groups of rats gained more weight than
the control group (p<0.05) which had progressive weight loss. Colon weight, macroscopic, and microscopic damage scores for the Gln groups
were lower than in the control group (p<0.05). IL-8 and TNF-
concentrations in inflamed colonic tissues were lower in the Gln groups
than in the control group (p<0.05), and correlated well with disease
severity. Bacterial translocation was lower both in incidence (p<0.05)
and in the number of colony forming units (p<0.05) for the Gln groups,
than in the control group. With respect to all indices studied, the 4%
Gln group performed better than did the 2% Gln group.
ConclusionProphylactic glutamine supplementation
modulates the inflammatory activities of IL-8 and TNF- in TNBS
induced colitis.
(GUT 1997;41:487-493)
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