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M P Mintchev
a Department of Electrical and Computer Engineering,
University of Calgary, b Department of
Surgery, University of Alberta, Edmonton, Alberta, Canada
Correspondence to: Dr M P Mintchev, Department
of Electrical and Computer Engineering, University of Calgary, Calgary,
Alberta,Canada T2N 1N4. Accepted for publication 29 April 1998 Background Keywords:
gastric electrical stimulation;
gastric motility
Gastric electrical stimulation has
been attempted for several years with little success.
AimsTo determine whether movement of liquid
gastric content could be achieved using microprocessor controlled
sequential electrical stimulation.
MethodsEight anaesthetised dogs underwent
laparotomy and implantation of four sets of bipolar stainless steel
wire electrodes. Each set consisted of two to six electrodes (10×0.25
mm, 3 cm apart) implanted circumferentially. The stomach was filled
with water and the process of gastric emptying was monitored.
Artificial contractions were produced using microprocessor controlled
phase locked bipolar four second trains of 50 Hz, 14 V (peak to peak) rectangular voltage. In four of the dogs four force transducers were
implanted close to each circumferential electrode set. In one
gastroparetic patient the effect of direct electrical stimulation was
determined at laparotomy.
ResultsUsing the above stimulating parameters
circumferential gastric contractions were produced which were
artificially propagated distally by phase locking the stimulating
voltage. Averaged stimulated gastric emptying times were significantly shorter than spontaneus emptying times (t1/2 6.7 (3.0)
versus 25.3 (12.9) minutes, p<0.01). Gastric electrical stimulation of the gastroparetic patient at operation produced circumferential contractions.
ConclusionsMicroprocessor controlled electrical
stimulation produced artificial peristalsis and notably accelerated the
movement of liquid gastric content.
(GUT 1998;43:607-611)
This article has been cited by other articles:
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  C. P. Sanmiguel, M. Hagiike, M. P. Mintchev, R. D. Cruz, E. H. Phillips, S. A. Cunneen, J. L. Conklin, and E. E. Soffer Effect of electrical stimulation of the LES on LES pressure in a canine model Am J Physiol Gastrointest Liver Physiol, August 1, 2008; 295(2): G389 - G394. [Abstract] [Full Text] [PDF]
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 H. Zhu, H. Sallam, D. D. Chen, and J. D. Z. Chen Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1875 - R1881. [Abstract] [Full Text] [PDF]
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 M A Amaris, P Z Rashev, M P Mintchev, and K L Bowes Microprocessor controlled movement of solid colonic content using sequential neural electrical stimulation Gut, April 1, 2002; 50(4): 475 - 479. [Abstract] [Full Text] [PDF]
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