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Chr Löser
a I Medical
Department, Christian-Albrechts University, Schittenhelmstrasse 12, D-24105 Kiel, Germany, b Institute of Pathology,
Christian-Albrechts- University, Kiel, Germany
Correspondence to: Professor Löser. Accepted for publication 22 July 1998
Background Keywords:
colon;
gut;
nutrition;
ornithine decarboxylase;
polyamines;
polyamine deficient diet
Polyamines are essential
for cell growth. Dietary and probably gut bacterial derived polyamines
contribute significantly to the polyamine body pool.
AimsTo evaluate the influence of
dietary, luminal polyamines on growth and development of different
gastrointestinal organs in normally growing rats.
MethodsMale suckling Wistar
rats were randomly allocated to four treatment groups: polyamine
deficient diet (PDD); PDD plus antibiotics (neomycin 2 g/kg and
metronidazole 34 mg/kg); PDD plus polyamine supplementation at normal
concentrations; or normal standard laboratory chow. After a six month
feeding period 7-10 animals/group were sacrificed.
ResultsNo differences in
body weight gain, food consumption, or general behaviour could be
observed between the four groups of animals. Feeding of PDD alone or
PDD plus antibiotics resulted in a highly significant decrease in organ
weight, protein content, and DNA content in small intestinal and
colonic mucosa whereas no alterations were found in the liver.
ConclusionsLong term feeding of
polyamine deficient diets resulted in a significant hypoplasia of
small intestinal and colonic mucosa. Dietary, luminal polyamines
are important local factors for growth and the development of small
intestinal and colonic mucosa.
(GUT 1998;44:12-16)
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