| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
R J Playford
a University Division
of Gastroenterology, Leicester General Hospital, Gwendolen Road,
Leicester LE5 4PW, UK, b Histopathology Unit, Imperial Cancer Research
Fund, 35 Correspondence to: Professor
Playford. Accepted for publication 13 January 1999
BACKGROUND Keywords:
gastrointestinal tract;
intestinal injury;
repair;
nutrition
43 Lincoln's Inn Fields, London WC1A 3PN, UK, c Scientific Hospital
Supplies International Ltd, 100 Wavertree Boulevard, Liverpool L7 9PT,
UK
Non-steroidal
anti-inflammatory drugs (NSAIDs) are effective for arthritis but
cause gastrointestinal injury. Bovine colostrum is a rich source of
growth factors and is marketed as a health food supplement.
AIMSTo examine whether spray
dried, defatted colostrum or milk preparations could reduce
gastrointestinal injury caused by indomethacin.
METHODSEffects of test solutions,
administered orally, were examined using an indomethacin restraint rat
model of gastric damage and an indomethacin mouse model of small
intestinal injury. Effects on migration of the human colonic carcinoma
cell line HT-29 and rat small intestinal cell line RIE-1 were assessed
using a wounded monolayer assay system (used as an in vitro model of wound repair) and effects on proliferation determined using
[3H]thymidine incorporation.
RESULTSPretreatment with 0.5 or 1 ml colostral preparation reduced gastric injury by 30% and 60%
respectively in rats. A milk preparation was much less efficacious.
Recombinant transforming growth factor 
added at a dose similar to
that found in the colostrum preparation (12.5 ng/rat), reduced injury
by about 60%. Addition of colostrum to drinking water (10% vol/vol)
prevented villus shortening in the mouse model of small intestinal
injury. Addition of milk preparation was ineffective. Colostrum
increased proliferation and cell migration of RIE-1 and HT-29 cells.
These effects were mainly due to constituents of the colostrum with
molecular weights greater than 30 kDa.
CONCLUSIONSBovine colostrum could
provide a novel, inexpensive approach for the prevention and treatment
of the injurious effects of NSAIDs on the gut and may also be of value
for the treatment of other ulcerative conditions of the bowel.
(Gut 1999;44:653-658)
This article has been cited by other articles:
|
|
 |
|
  M. R. Cesarone, G. Belcaro, A. Di Renzo, M. Dugall, M. Cacchio, I. Ruffini, L. Pellegrini, G. Del Boccio, F. Fano, A. Ledda, et al. Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentino Clinical and Applied Thrombosis/Hemostasis, April 1, 2007; 13(2): 130 - 136. [Abstract] [PDF]
|
|
|
|
 |
|
 C. E. Commare and K. A. Tappenden Development of the Infant Intestine: Implications for Nutrition Support Nutr Clin Pract, April 1, 2007; 22(2): 159 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Mahmood, A J FitzGerald, T Marchbank, E Ntatsaki, D Murray, S Ghosh, and R J Playford Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes Gut, February 1, 2007; 56(2): 168 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Belo, T Marchbank, A Fitzgerald, S Ghosh, and R J Playford Gastroprotective effects of oral nucleotide administration Gut, February 1, 2006; 55(2): 165 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A J Fitzgerald, P S Rai, T Marchbank, G W Taylor, S Ghosh, B W Ritz, and R J Playford Reparative properties of a commercial fish protein hydrolysate preparation Gut, June 1, 2005; 54(6): 775 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Prosser, K. Stelwagen, R. Cummins, P. Guerin, N. Gill, and C. Milne Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders J Appl Physiol, February 1, 2004; 96(2): 650 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D Tran, G. S Howarth, P. Coyle, J. C Philcox, A. M Rofe, and R. N Butler Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1296 - 1303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Gookin, J. M. Rhoads, and R. A. Argenzio Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum Am J Physiol Gastrointest Liver Physiol, July 1, 2002; 283(1): G157 - G168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J Playford, C. E Macdonald, and W. S Johnson Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders Am. J. Clinical Nutrition, July 1, 2000; 72(1): 5 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Marchbank, H. M. Cox, R. A. Goodlad, A. S. Giraud, S. F. Moss, R. Poulsom, N. A. Wright, J. Jankowski, and R. J. Playford Effect of Ectopic Expression of Rat Trefoil Factor Family 3 (Intestinal Trefoil Factor) in the Jejunum of Transgenic Mice J. Biol. Chem., June 22, 2001; 276(26): 24088 - 24096. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
