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S Freier
a Laboratory of
Mucosal Immunology, Shaare Zedek Medical Center, Jerusalem, Israel, b Department of
Oncology, Shaare Zedek Medical Center, c Departments of Internal Medicine and Surgery,
Hadassah Medical Centre, Jerusalem, Israel, d Institute
of Experimental Clinical Research, Aarhus Kommunehospital, Aarhus,
Denmark
Correspondence to: Professor
S Freier, Laboratory of Mucosal Immunology, Shaare Zedek Medical
Centre, Jerusalem 91031, Israel. Accepted for publication 4 November 1998
AIMS Keywords:
insulin-like growth factors;
adenocarcinoma;
colon
To study changes
in the expression of insulin-like growth factors (IGFs) and their
receptors, as well as production of the IGF-I and IGF-II polypeptides,
in adenocarcinoma of the colon.
METHODSMalignant
tissue obtained at operation was used. Total RNA was extracted and
specific IGF-I and IGF-II and their receptor mRNAs were measured by a
solution hybridisation RNase protection assay. IGF-I and IGF-II
polypeptides were measured by specific immunoassays.
RESULTSAll normal
tissues expressed IGF-II, IGF-I receptor, and
IGF-II/mannose-6-phosphate (Man-6-P) receptor. IGF-I mRNA could not be
detected but the polypeptide was present in small but equal amounts in
normal and malignant tissue. IGF-II was expressed 40 times more
abundantly in colonic tumours than in adjacent normal tissue and the
concentration of the corresponding polypeptide was twice as high in the
malignant tissue. IGF-I receptor expression was increased by a factor
of 2.5 and IGF-II/Man-6-P receptor by a factor of 4.
CONCLUSIONSThis study
confirms that in adenocarcinoma of the human colon there is increased
expression of IGF-I receptor and IGF-II. Furthermore, IGF-II/Man-6-P
receptor message is increased and the increase in IGF-II message is
accompanied by a doubling of the IGF-II protein in the tumour tissue
compared with the adjacent normal tissue. These findings suggest that
the IGF-II/Man-6-P receptor may also be involved in development of
adenocarcinoma of the colon. There is rapidly accumulating evidence
implicating the IGF system in the development of malignancy of the
large bowel.
(Gut 1999;44:704-708)
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