Gut

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buts, J-P
Right arrow Articles by Tulkens, P M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buts, J-P
Right arrow Articles by Tulkens, P M
Gut 1999;45:89-96 ( July )

Article

Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats J-P Butsa, N De Keysera, S Marandia, D Hermansa, E M Sokala, Y-H E Chaeb, L Lambotteb, H Chanteuxc, P M Tulkensc

a Laboratory of Paediatric Gastroenterology and Nutrition, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium, b Laboratory of Experimental Surgery, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium , c Unit of Cellular and Molecular Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium

Correspondence to: Dr J-P Buts, Department of Pediatrics, Cliniques Universitaires St-Luc, 10 Avenue Hippocrate, B-1200 Brussels, Belgium.

Accepted for publication 2 February 1999

BACKGROUND---Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa.
AIMS---To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats.
METHODS---Wistar rats, aged eight weeks, underwent 60% proximal resection or transection and received by orogastric intubation either 1 mg/g body wt per day lyophilised S boulardii or the vehicle for seven days. The effects on ileal mucosal adaptation were assessed eight days after surgery.
RESULTS---Compared with transection, resection resulted in mucosal hyperplasia with significant decreases in the specific and total activities of sucrase, lactase, and maltase. Treatment of resected animals with S boulardii had no effect on mucosal hyperplasia but did upgrade disaccharidase activities to the levels of the transected group. Enzyme stimulation by S boulardii was associated with significant increases in diamine oxidase activity and mucosal polyamine concentrations. Likewise, sodium dependent D-glucose uptake by brush border membrane vesicles, measured as a function of time and glucose concentration in the incubation medium, was significantly (p<0.05) increased by 81% and three times respectively in the resected group treated with S boulardii. In agreement with this, expression of the sodium/glucose cotransporter-1 in brush border membranes of resected rats treated with S boulardii was enhanced twofold compared with resected controls.
CONCLUSION---Oral administration of S boulardii soon after proximal enterectomy improves functional adaptation of the remnant ileum.


Keywords: Saccharomyces boulardii; intestine; adaptation; polyamines; brush border membrane enzymes; glucose uptake

© 1999 by Gut


This article has been cited by other articles:


Home page
 JRSMHome page
O. Epstein
Green medicine
J R Soc Med, May 1, 2005; 98(5): 203 - 205.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1999 BMJ Publishing Group Ltd & British Society of Gastroenterology