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a Pathogénie
Bactérienne Intestinale, Laboratoire de Bactériologie, Université
d'Auvergne, Clermont-Ferrand, France, b Laboratoire de Recherche sur les Maladies
Inflammatoires de l'Intestin, CHRU, Lille, France, c Laboratoire de Bactériologie, Faculté de
Pharmacie, Lille, France
Correspondence to: A Darfeuille-Michaud, Pathogénie Bactérienne Intestinale, Laboratoire de Bactériologie, Université d'Auvergne, 28 Place Henri Dunant, 63001 Clermont-Ferrand Cedex, France. arlette.darfeuille-michaud{at}u-clermont1.fr
Accepted for publication 31 October 2000
Escherichia coli
strains isolated from patients with Crohn's
disease (CD) with chronic ileal lesions (n=14), early endoscopic recurrent lesions (n=20), without endoscopic recurrence (n=7), and
controls (n=21) were compared by ribotyping. The dendrogram generated
by 50 ribotype profile analysis revealed a large cluster of genetically
linked E coli strains isolated significantly
more frequently from patients with chronic and recurrent CD (24/33 patients) than from controls (9/21) (p<0.05). Most patients operated on for chronic ileal lesions (78.5%) harboured E
coli strains belonging to cluster A (p<0.002
v controls). The prevalence of patients with
early recurrent lesions harbouring E coli
strains belonging to this cluster was high but not significant,
although 16 strains isolated from eight patients presented the same
ribotype profile. In this cluster, 21 of 26 strains isolated from
patients with active CD demonstrated adherent ability to differentiated Caco-2 cells, indicating that most of the genetically related strains
share a common virulence trait. Comparison of E
coli strains recovered from ulcerated and healthy mucosa of
patients operated on for CD demonstrated in each patient that a single
strain colonised the intestinal mucosa. Our results suggest that
although a single E coli isolate was not
found in Crohn's ileal mucosa, some genotypes were more likely than
others to be associated with chronic or early recurrent ileal lesions.
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