| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Division of
Molecular and Genetic Medicine, University of Sheffield, Sheffield, UK, b Gastroenterology and Liver Unit, Royal
Hallamshire Hospital, Sheffield, UK
Correspondence to: Dr M J Carter, Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK. m.j.carter{at}shef.ac.uk
Accepted for publication 14 November 2000
BACKGROUND AND AIMS
An
association between the allele 2 of the interleukin 1 receptor
antagonist gene variable number tandem repeats polymorphism in intron 2 and ulcerative colitis was first reported in 1994. Subsequent studies
in Caucasian Northern European patients have not confirmed this,
although trends towards an association were observed. The lack of
statistical significance could reflect inadequate power. In this study
the association was reassessed in a large independent set of well
characterised Caucasian patients and a meta-analysis of reported
patient series was performed.
PATIENTS
AND
METHODSA total of 320 patients with
endoscopically and histologically confirmed ulcerative colitis (124 pancolitis, 196 left sided and distal disease) and 827 ethnically
matched controls were genotyped at polymorphic sites in the interleukin
1 receptor antagonist gene. Carriage rates were compared using
2 statistics. A meta-analysis of this and seven previous
studies in North European Caucasian patients was performed using the
Mantel-Haenszel 2 test.
RESULTSPatients had a
significantly increased carriage rate of allele 2 compared with
controls (52% v 45%; odds ratio 1.3 (95%
confidence interval (CI) 1.01-1.7); p=0.04). The allele 2 carriage
rate was highest in extensive colitis (carriage rate 56%; odds ratio
1.5 (95% CI 1.1-2.3) p=0.02) and in individuals who had undergone colectomy (carriage rate 55%; odds ratio 1.5 (95% CI 0.95-2.4); p=0.08). Meta-analysis of all eight studies showed a significant association between carriage of allele 2 and ulcerative colitis (odds
ratio 1.23 (95% CI 1.04-1.45); p=0.01).
CONCLUSIONSThe
association of the interleukin 1 receptor antagonist gene polymorphism
with ulcerative colitis is confirmed. The association is minor and
confers only a small risk to an individual but will contribute a high
attributable risk in a population due to the high allelic frequency.
Accurate phenotypic characterisation defines more homogeneous subsets
of patients, such as those with extensive disease, in whom the
association is greater.
This article has been cited by other articles:
|
|
 |
|
  J. A. Greenhall, M. A. Zapala, M. Caceres, O. Libiger, C. Barlow, N. J. Schork, and D. J. Lockhart Detecting genetic variation in microarray expression data Genome Res., August 1, 2007; 17(8): 1228 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Karban, T. Okazaki, C. I.M. Panhuysen, T. Gallegos, J. J. Potter, J. E. Bailey-Wilson, M. S. Silverberg, R. H. Duerr, J. H. Cho, P. K. Gregersen, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis Hum. Mol. Genet., January 1, 2004; 13(1): 35 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Read, C. Cannings, S. C. Naylor, J. M. Timms, R. Maheswaran, R. Borrow, E. B. Kaczmarski, and G. W. Duff Variation within Genes Encoding Interleukin-1 and the Interleukin-1 Receptor Antagonist Influence the Severity of Meningococcal Disease Ann Intern Med, April 1, 2003; 138(7): 534 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. McGarry, J. Neilly, N. Anderson, R. Sturrock, and M. Field A polymorphism within the interleukin 1 receptor antagonist (IL-1Ra) gene is associated with ankylosing spondylitis Rheumatology, December 1, 2001; 40(12): 1359 - 1364. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
