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Gut 2002;50:428-435
© 2002 by Gut

REVIEW

Gut adaptation and the glucagon-like peptides

D J Drucker

Correspondence to:
Correspondence to:
D J Drucker, The Banting and Best Diabetes Centre, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2C4
d.drucker{at}utoronto.ca

The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 may enhance energy absorption and reduce fluid loss in subjects with short bowel syndrome suggesting that GLP-2 functions as a key regulator of mucosal integrity, permeability, and nutrient absorption. Hence GLP-2 may be therapeutically useful in diseases characterised by injury or dysfunction of the gastrointestinal epithelium.

Keywords: short bowel; intestine; gut adaptation; glucagon-like peptides; enteroendocrine; appetite; mucositis; nutrition

Abbreviations: GLP-1, GLP-2, glucagon-like peptides 1 and 2; GLI, glucagon-like immunoreactivity; PGDP, proglucagon derived peptide; IP-1, IP-2, intervening peptides 1 and-2; DP IV, dipeptidyl peptidase IV; PKA, protein kinase A; GLP-2R, GLP-2 receptor




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