| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
LIVER DISEASE |
1 Centre for Liver and Digestive Disorders and Department of Medicine, Royal Infirmary of Edinburgh, UK
2 Medical School, University of Edinburgh, UK
3 Department of Radiology, Royal Infirmary, Edinburgh, UK
Correspondence to:
Correspondence to:
D Tripathi, Department of Medicine, Royal Infirmary of Edinburgh, 1 Lauriston Place, Edinburgh EH3 9YW, UK;
d.tripathi{at}ed.ac.uk
ABSTRACT
Background: The transjugular intrahepatic portosystemic stent shunt (TIPSS) is effective in the management of both oesophageal and gastric variceal bleeding. Although it has been reported that gastric varices can bleed at pressures of 
12 mm Hg, this phenomenon has been little studied in the clinical setting.
Aims: To assess the efficacy of TIPSS on rebleeding and mortality following gastric and oesophageal variceal bleeding, and the importance of portal pressure in both groups.
Methods: Forty eligible patients who had bled from gastric varices and 232 from oesophageal varices were studied. Patients were also subdivided into those whose portal pressure gradients (PPG) prior to TIPSS were 12 mm Hg (group 1) and >12 mm Hg (group 2).
Results: There was no difference in Child-Pugh score, age, sex, or alcohol related disease between patients bleeding from gastric or oesophageal varices. Patients who bled from gastric varices had a lower PPG pre-TIPSS (15.8 (0.8) v 21.44 (0.4) mm Hg; p<0.001). There was no difference in the rebleeding rate (20.0% v 14.7%; NS). There was a significant difference (p<0.05) in favour of the gastric varices group in the one year mortality (30.7% v 38.7%) and five year mortality (49.5% v 74.9%), particularly in those patients in group 2. Gastric variceal bleeding accounted for significantly more cases in group 1 than in group 2 (36.8% v 10.2%; p<0.001). Most patients in group 2 who rebled had a PPG post-TIPSS of >7 mm Hg.
Conclusions: TIPSS is equally effective in the prevention of rebleeding following gastric and oesophageal variceal bleeding. A significant proportion of gastric varices bleed at a PPG 12 mm Hg. The improved mortality in patients with gastric variceal bleeding is seen only in those that bleed at a PPG >12 mm Hg, and warrants further study.
Keywords: transjugular intrahepatic portosystemic stent shunt; portal pressure gradient; gastric variceal bleeding; portal hypertension
Abbreviations: TIPSS, transjugular intrahepatic portosystemic stent shunt; PPG, portal pressure gradient; GVB, gastric variceal bleeding; OVB, oesophageal variceal bleeding; HVPG, hepatic venous pressure gradient
This article has been cited by other articles:
|
|
 |
|
  Abstracts Gut, April 1, 2007; 56(suppl_2): a1 - a145. [Full Text] [PDF]
|
|
|
|
 |
|
 D N Samonakis, C K Triantos, U Thalheimer, D W Patch, and A K Burroughs Management of portal hypertension Postgrad. Med. J., November 1, 2004; 80(949): 634 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ninoi, K. Nakamura, T. Kaminou, N. Nishida, Y. Sakai, T. Kitayama, M. Hamuro, R. Yamada, T. Arakawa, and Y. Inoue TIPS Versus Transcatheter Sclerotherapy for Gastric Varices Am. J. Roentgenol., August 1, 2004; 183(2): 369 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B M Ryan, R W Stockbrugger, J M Ryan, D Tripathi, G Therapondos, P C Hayes, and D N Redhead TIPS for gastric varices Gut, May 1, 2003; 52(5): 772 - 772. [Full Text]
|
|
Read all eLetters
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
