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Recent advances in basic science
Tracing PAKs from GI inflammation to cancer
  1. Kyle Dammann,
  2. Vineeta Khare,
  3. Christoph Gasche
  1. Department of Medicine III, Division of Gastroenterology and Hepatology and Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
  1. Correspondence to Professor Christoph Gasche, Division of Gastroenterology and Hepatology, Medical University of Vienna, Währinger Gürtel 18-20A-1090, Vienna A-1090, Austria; christoph.gasche{at}meduniwien.ac.at

Abstract

P-21 activated kinases (PAKs) are effectors of Rac1/Cdc42 which coordinate signals from the cell membrane to the nucleus. Activation of PAKs drive important signalling pathways including mitogen activated protein kinase, phospoinositide 3-kinase (PI3K/AKT), NF-κB and Wnt/β-catenin. Intestinal PAK1 expression increases with inflammation and malignant transformation, although the biological relevance of PAKs in the development and progression of GI disease is only incompletely understood. This review highlights the importance of altered PAK activation within GI inflammation, emphasises its effect on oncogenic signalling and discusses PAKs as therapeutic targets of chemoprevention.

  • INFLAMMATORY BOWEL DISEASE
  • COLON CARCINOGENESIS
  • GASTROINTESTINAL CANCER

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

https://doi.org/10.1136/gutjnl-2014-306768

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      Correction
      BMJ Publishing Group Ltd and British Society of Gastroenterology
      Gut 2014; 63 1368-1368 Published Online First: 08 Jul 2014. doi: 10.1136/gutjnl-2014-306768corr1