Article Text
Abstract
Background We have previously used a magnetic resonance imaging (MRI) method to study gastric emptying of liquids. So far, however, it has not possible to assess solid gastric emptying with this technique.
Aims To validate scintigraphically MRI as a method for measuring emptying of a mixed solid/liquid meal.
Methods In eight healthy subjects, gastric emptying of a solid/liquid (SM) and a liquid meal (LM) of identical energy content and macronutrient composition was studied by scintigraphy and MRI for 120 minutes.
Results MRI and scintigraphy agreed with respect to emptying profiles (intraclass correlation coefficient (RI) SM: 0.988, RI, LM: 0.917), t1/2 (SMMRI: 129 (9), SMScinti: 123 (11) minutes, NS; LMMRI: 100 (7), LMScinti: 110 (8) minutes, NS) and AUC (SMMRI: 8999 (232), SMScinti: 8788 (277) min%, NS; LMMRI: 8819 (368), LMScinti: 8891 (321) min%, NS).
Conclusions MRI can be used to measure reliably gastric emptying not only of liquid but also of mixed solid/liquid meals in humans.
- magnetic resonance imaging
- scintigraphy
- gastric emptying
- solid meal
- liquid meal
Abbreviations
- MRI
- magnetic resonance imaging
- Gd-DOTA
- gadolinium tetraazacyclododecane tetraacetic acid
- AUC
- area under the curve
- RI
- intraclass correlation coefficient