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The promise of gene therapy in gastrointestinal and liver diseases

Abstract

Gene therapy consists of the transfer of genetic material to cells to achieve a therapeutic goal. In the field of gastroenterology and hepatology gene therapy has produced considerable expectation as a potential tool in the management of conditions that lack effective therapy including non-resectable neoplasms of the liver, pancreas and gastrointestinal tract, chronic viral hepatitis unresponsive to interferon therapy, liver cirrhosis, and inflammatory bowel disease.

  • gene therapy
  • AAV, adeno-associated viruses
  • HSV, herpes simplex virus
  • GI, gastrointestinal
  • IL, interleukin
  • IFN, interferon
  • WHV, woodchuck hepatitis virus

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