You are here

Article Text

Article menu
Download PDFPDF
Gastrointestinal motility
Local regulation of postprandial motor responses in ileal pouches
  1. A Mularczyka,
  2. E Contessini-Avesanib,
  3. B Cesanac,
  4. P A Bianchia,
  5. G Basiliscoa
  1. aCattedra di Gastroenterologia, Istituto di Scienze Mediche, Università degli Studi di Milano, Milan, Italy, bCattedra di Chirurgia dell’Apparato Digerente dell’ Università degli Studi di Milano, Milan, Italy, cLaboratorio Epidemiologico, IRCCS-Ospedale Maggiore di Milano, Milan, Italy
  1. Dr G Basilisco, Department of Gastroenterology, Padiglione Granelli, Via F Sforza 35, 20122 Milan, Italy.

Abstract

BACKGROUND Local mechanisms are involved in the postprandial regulation of ileal tone in healthy subjects, but whether these mechanisms affect the postprandial tonic response of ileal pouches has not yet been investigated.

AIMS To study the effect of a meal on pouch tone and phasic motor activity in patients with gut continuity or ileostomy and, in the latter group, the effect of a pouch perfusion with chyme or saline.

PATIENTS Twenty patients with ileal pouches: 10 with gut continuity and 10 with ileostomy.

METHODS Pouch tone and the frequency of phasic volume events were recorded with a barostat under fasting and postprandial conditions and after perfusion of the isolated pouch with chyme or saline.

RESULTS The meal increased pouch tone and the frequency of phasic volume events in the patients with gut continuity, but not in those with ileostomy. Pouch perfusion with chyme induced a greater increase in pouch tone than saline.

CONCLUSIONS The meal stimulated pouch tone and phasic motor activity. These effects were at least partially related to local pouch stimulation by intraluminal contents.

  • ileal pouches
  • postprandial motor responses
  • ileal tone
  • ileostomy
  • motor activity
  • barostat

https://doi.org/10.1136/gut.45.4.575

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text