You are here

  • Home
  • Archive
  • Volume 68, Issue 2
  • Multicentre prospective evaluation of real-time optical diagnosis of T1 colorectal cancer in large non-pedunculated colorectal polyps using narrow band imaging (the OPTICAL study)

Article Text

Article menu
Download PDFPDF
Endoscopy
Original article
Multicentre prospective evaluation of real-time optical diagnosis of T1 colorectal cancer in large non-pedunculated colorectal polyps using narrow band imaging (the OPTICAL study)
  1. Yara Backes1,
  2. Matthijs P Schwartz2,
  3. Frank ter Borg3,
  4. Frank H J Wolfhagen4,
  5. John N Groen5,
  6. Wouter H de Vos tot Nederveen Cappel6,
  7. Jeroen van Bergeijk7,
  8. Joost M J Geesing8,
  9. Bernhard W M Spanier9,
  10. Paul Didden1,
  11. Frank P Vleggaar1,
  12. Miangela M Lacle10,
  13. Sjoerd G Elias11,
  14. Leon M G Moons1
  15. on behalf of the Dutch T1 CRC Working Group
  1. 1 Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands
  2. 2 Department of Gastroenterology and Hepatology, Meander Medical Center, Amersfoort, The Netherlands
  3. 3 Department of Gastroenterology and Hepatology, Deventer Hospital, Deventer, The Netherlands
  4. 4 Department of Gastroenterology and Hepatology, Albert Schweitzer Hospital, Dordrecht, The Netherlands
  5. 5 Department of Gastroenterology and Hepatology, Sint Jansdal Hospital, Harderwijk, The Netherlands
  6. 6 Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands
  7. 7 Department of Gastroenterology and Hepatology, Gelderse Vallei Hospital, Ede, The Netherlands
  8. 8 Department of Gastroenterology and Hepatology, Diakonessenhuis, Utrecht, The Netherlands
  9. 9 Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands
  10. 10 Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
  11. 11 Julius Center for Health Sciences and Primary Care, University Medical Center, University Utrecht, Utrecht, The Netherlands
  1. Correspondence to Dr Leon M G Moons, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands; L.M.G.Moons{at}umcutrecht.nl

Abstract

Objective This study evaluated the preresection accuracy of optical diagnosis of T1 colorectal cancer (CRC) in large non-pedunculated colorectal polyps (LNPCPs).

Design In this multicentre prospective study, endoscopists predicted the histology during colonoscopy in consecutive patients with LNPCPs using a standardised procedure for optical assessment. The presence of morphological features assessed with white light, and vascular and surface pattern with narrow-band imaging (NBI) were recorded, together with the optical diagnosis, the confidence level of prediction and the recommended treatment. A risk score chart was developed and validated using a multivariable mixed effects binary logistic least absolute shrinkage and selection (LASSO) model.

Results Among 343 LNPCPs, 47 cancers were found (36 T1 CRCs and 11 ≥T2 CRCs), of which 11 T1 CRCs were superficial invasive T1 CRCs (23.4% of all malignant polyps). Sensitivity and specificity for optical diagnosis of T1 CRC were 78.7% (95% CI 64.3 to 89.3) and 94.2% (95% CI 90.9 to 96.6), and 63.3% (95% CI 43.9 to 80.1) and 99.0% (95% CI 97.1 to 100.0) for optical diagnosis of endoscopically unresectable lesions (ie, ≥T1 CRC with deep invasion), respectively. A LASSO-derived model using white light and NBI features discriminated T1 CRCs from non-invasive polyps with a cross-validation area under the curve (AUC) of 0.85 (95% CI 0.80 to 0.90). This model was validated in a temporal validation set of 100 LNPCPs (AUC of 0.81; 95% CI 0.66 to 0.96).

Conclusion Our study provides insights in the preresection accuracy of optical diagnosis of T1 CRC. Sensitivity is still limited, so further studies will show how the risk score chart could be improved and finally used for clinical decision making with regard to the type of endoresection to be used and whether to proceed to surgery instead of endoscopy.

Trial registration number NTR5561.

  • colorectal adenomas
  • colorectal cancer
  • colonoscopy
  • colorectal carcinoma

https://doi.org/10.1136/gutjnl-2017-314723

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors YB, MPS, FtB, FHJW, JNG, WHdVtNC, JvB, JMJG, BWMS, FPV, MML, SGE, LMGM: study concept and design. YB, LMGM: study supervision. YB, MPS, FtB, FHJW, JNG, WHdVtNC, JvB, JMJG, BWMS, PD, FPV, MML, LMGM: patient inclusion, acquisition and interpretation of data. YB, SGE, LMGM: data analysis. YB, SGE, LMGM: drafting of the manuscript. LM: principal investigator. All authors were involved in critical revision of manuscript.

    • Competing interests None declared.

    • Ethics approval University Medical Centre Utrecht.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement Individual participant data that underlie the results reported in this article are available from the corresponding author following publication on reasonable request, after de-identification (text, tables, figures and appendices).