Table 1

Predictor variables contained within the 16 identified eligible colorectal cancer risk prediction models

Author	Sex	Outcome	Predictor variables
			Demographic characteristics				Anthropometry		Family history of Cancer	Medical history				Medication use			Lifestyle factors			Diet
			Sex	Age	Eth	Edu	Height	BMI	Family history of Cancer	Diabetes	Screen/endo/ polyp	IBD	Menopausal status	HRT	OC	NSAID	Physical activity	Smoking	Alcohol	Red meat/ meat	Veg	Vit
Colditz23	M	C		●			●	●	●		●	●				●	●		●	●	●	●
	F	C		●			●	●	●		●	●		●	●	●	●		●	●	●	●
Driver24	M	CRC		●				●										●	●
Freedman7	M	CRC		●				●	●		●					●	●	●			●
	F	CRC		●				●	●		●		○ α	○ α		●	●				●
Ma9	M	CRC		●				●									●	●	●
	M	C		●				●									●	●	●
	M	R		●													●		●
Shin25	M	R C		●				●	●										●	●
	F	R		●			●												●	●
Steffen10	Both	CRC	●	●				●		●	●							●	●
	Both	C	●	●				●		●	●							●	●
	Both	R	●	●				●		●	●							●	●
Taylor8	Both	CRC		●					●
Wells26	M	CRC		●	●	●		●	●	●						●	●	●	●	●		●
	F	CRC		●	●	●		●	●	●				○ µ	○ µ	●		●	●			●
Variable availability in EPIC			■	■		□	■	■	□	■	□		na	□	□	□	■	■	■	□	□	□
Variable availability in UK Biobank			■	■	■	□	■	■	□	■	■	■	na	□	□	□	□	■	■	□	□	■

●, variable included in the original model; ○, two variables amalgamated to create a new variable that was included in the model. The names of these variables were: α, oestrogen status; µ, oestrogen. Family history of cancer varied by both cancer site and degrees of relatedness between models. ■, available in a construction directly suitable for at least one model; □, variable required to be derived from other variable(s) in the dataset for all models that used it; na, not applicable as the variable is amalgamated in the model in which it is used. See online supplementary table 1 for further details.
BMI, body mass index; C, colon cancer; CRC, colorectal cancer; Edu, years of education; EPIC, European Prospective Investigation into Cancer and Nutrition; Eth, ethnicity; F, female; HRT, hormone replacement therapy; IBD, inflammatory bowel disease; M, male; NSAID, non-steroidal anti-inflammatory drug; OC, oral contraceptive; R, rectal cancer; RC, right colon cancer; screen/endo/polyp, history of colorectal cancer screening or lower gastrointestinal endoscopy with or without identification of polyps; Veg, vegetables; Vit, multivitamin.