Interleukins

IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling
Mircea Teodor Chiriac, Zsuzsanna Hracsko, Claudia Günther, Miguel Gonzalez-Acera, Raja Atreya, Iris Stolzer, Leonie Wittner, Anja Dressel, Laura Schickedanz, Reyes Gamez-Belmonte, Lena Erkert, Gheorghe Hundorfean, Sebastian Zundler, Timo Rath, Stefania Vetrano, Silvio Danese, Gregor Sturm, Zlatko Trajanoski, Anja A Kühl, Britta Siegmund, Arndt Hartmann, Stefan Wirtz, Jürgen Siebler, Susetta Finotto, Christoph Becker, Markus F Neurath

Gut Feb 2024, 73 (2) 282-297; DOI: 10.1136/gutjnl-2023-329628
Interleukin-11 drives human and mouse alcohol-related liver disease
Maria Effenberger, Anissa A Widjaja, Felix Grabherr, Benedikt Schaefer, Christoph Grander, Lisa Mayr, Julian Schwaerzler, Barbara Enrich, Patrizia Moser, Julia Fink, Alisa Pedrini, Nikolai Jaschke, Alexander Kirchmair, Alexandra Pfister, Bela Hausmann, Reto Bale, Daniel Putzer, Heinz Zoller, Sebastian Schafer, Petra Pjevac, Zlatko Trajanoski, Georg Oberhuber, Timon Adolph, Stuart Cook, Herbert Tilg

Gut Jan 2023, 72 (1) 168-179; DOI: 10.1136/gutjnl-2021-326076
Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
Frank Wagner, John C Mansfield, Annemarie N Lekkerkerker, Yehong Wang, Mary Keir, Ajit Dash, Brandon Butcher, Brandon Harder, Luz D Orozco, Jordan S Mar, Hao Chen, Michael E Rothenberg

Gut Aug 2023, 72 (8) 1451-1461; DOI: 10.1136/gutjnl-2022-328387
Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours
Lindsay Kathleen Dickerson, Jason A Carter, Karan Kohli, Venu G Pillarisetty

Gut Aug 2023, 72 (8) 1592-1606; DOI: 10.1136/gutjnl-2023-329650
Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases
Kevin M Sullivan, Xiuyun Jiang, Prajna Guha, Christopher Lausted, Jason A Carter, Cynthia Hsu, Kevin P Labadie, Karan Kohli, Heidi L Kenerson, Sara K Daniel, Xiaowei Yan, Changting Meng, Arezou Abbasi, Marina Chan, Y David Seo, James O Park, Ian Nicholas Crispe, Raymond S Yeung, Teresa S Kim, Taranjit S Gujral, Qiang Tian, Steven C Katz, Venu G Pillarisetty

Gut Feb 2023, 72 (2) 325-337; DOI: 10.1136/gutjnl-2021-325808
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Xiaoting Sun, Xingkang He, Yin Zhang, Kayoko Hosaka, Patrik Andersson, Jing Wu, Jieyu Wu, Xu Jing, Qiqiao Du, Xiaoli Hui, Bo Ding, Ziheng Guo, An Hong, Xuan Liu, Yan Wang, Qing Ji, Rudi Beyaert, Yunlong Yang, Qi Li, Yihai Cao

Gut Jan 2022, 71 (1) 129-147; DOI: 10.1136/gutjnl-2020-322744
IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-γ dependent manner
S Chikano, K Sawada, T Shimoyama, S-I Kashiwamura, A Sugihara, K Sekikawa, N Terada, K Nakanishi, H Okamura

Gut Dec 2000, 47 (6) 779-786; DOI: 10.1136/gut.47.6.779
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig

Gut Jun 2021, 70 (6) 1023-1036; DOI: 10.1136/gutjnl-2020-321731
Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression
Ryota Takahashi, Marina Macchini, Masaki Sunagawa, Zhengyu Jiang, Takayuki Tanaka, Giovanni Valenti, Bernhard W Renz, Ruth A White, Yoku Hayakawa, C Benedikt Westphalen, Yagnesh Tailor, Alina C Iuga, Tamas A Gonda, Jeanine Genkinger, Kenneth P Olive, Timothy C Wang

Gut Feb 2021, 70 (2) 330-341; DOI: 10.1136/gutjnl-2019-319912
STING signalling protects against chronic pancreatitis by modulating Th17 response
Qinglan Zhao, Murli Manohar, Yi Wei, Stephen J Pandol, Aida Habtezion

Gut Oct 2019, 68 (10) 1827-1837; DOI: 10.1136/gutjnl-2018-317098

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