oncogenes

APC and P53 mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer
Yuhua Tian, Xin Wang, Zvi Cramer, Joshua Rhoades, Katrina N. Estep, Xianghui Ma, Stephanie Adams-Tzivelekidis, Bryson W. Katona, F Brad Johnson, Zhengquan Yu, M Andres Blanco, Christopher J Lengner, Ning Li

Gut Dec 2023, 72 (12) 2294-2306; DOI: 10.1136/gutjnl-2022-329140
Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium
Lochlan Fennell, Alexandra Kane, Cheng Liu, Diane McKeone, Gunter Hartel, Chang Su, Catherine Bond, Mark Bettington, Barbara Leggett, Vicki Whitehall

Gut Jun 2022, 71 (6) 1127-1140; DOI: 10.1136/gutjnl-2020-322166
Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer
Martin Pichler, Cristian Rodriguez-Aguayo, Su Youn Nam, Mihnea Paul Dragomir, Recep Bayraktar, Simone Anfossi, Erik Knutsen, Cristina Ivan, Enrique Fuentes-Mattei, Sang Kil Lee, Hui Ling, Tina Catela Ivkovic, Guoliang Huang, Li Huang, Yoshinaga Okugawa, Hiroyuki Katayama, Ayumu Taguchi, Emine Bayraktar, Rajat Bhattacharya, Paola Amero, William Ruixian He, Anh M Tran, Petra Vychytilova-Faltejskova, Christiane Klec, Diana L Bonilla, Xinna Zhang, Sanja Kapitanovic, Bozo Loncar, Roberta Gafà, Zhihui Wang, Vittorio Cristini, Samir M Hanash, Menashe Bar-Eli, Giovanni Lanza, Ondrej Slaby, Ajay Goel, Isidore Rigoutsos, Gabriel Lopez-Berestein, George Adrian Calin

Gut Oct 2020, 69 (10) 1818-1831; DOI: 10.1136/gutjnl-2019-318903
USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis
Lionel Costa, Sébastien Corre, Valérie Michel, Krysten Le Luel, Julien Fernandes, Jason Ziveri, Gregory Jouvion, Anne Danckaert, Nicolas Mouchet, David Da Silva Barreira, Javier Torres, Margarita Camorlinga, Mario Milco D'Elios, Laurence Fiette, Hilde De Reuse, Marie-Dominique Galibert, Eliette Touati

Gut Sep 2020, 69 (9) 1582-1591; DOI: 10.1136/gutjnl-2019-318640
S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development
Cyril Sobolewski, Daniel Abegg, Flavien Berthou, Dobrochna Dolicka, Nicolas Calo, Christine Sempoux, Margot Fournier, Christine Maeder, Anne-Sophie Ay, Pierre-Alain Clavien, Bostjan Humar, Jean-François Dufour, Alexander Adibekian, Michelangelo Foti

Gut Oct 2020, 69 (10) 1841-1854; DOI: 10.1136/gutjnl-2019-319019
Adeno-associated virus in the liver: natural history and consequences in tumour development
Tiziana La Bella, Sandrine Imbeaud, Camille Peneau, Iadh Mami, Shalini Datta, Quentin Bayard, Stefano Caruso, Theo Z Hirsch, Julien Calderaro, Guillaume Morcrette, Catherine Guettier, Valerie Paradis, Giuliana Amaddeo, Alexis Laurent, Laurent Possenti, Laurence Chiche, Paulette Bioulac-Sage, Jean-Frederic Blanc, Eric Letouze, Jean-Charles Nault, Jessica Zucman-Rossi

Gut Apr 2020, 69 (4) 737-747; DOI: 10.1136/gutjnl-2019-318281
Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance
Dai-Min Xiang, Wen Sun, Tengfei Zhou, Cheng Zhang, Zhuo Cheng, Shi-Chao Li, Weiqi Jiang, Ruoyu Wang, Gongbo Fu, Xiuliang Cui, Guojun Hou, Guang-Zhi Jin, Hengyu Li, Caiying Hou, Hui Liu, Hongyang Wang, Jin Ding

Gut Oct 2019, 68 (10) 1858-1871; DOI: 10.1136/gutjnl-2018-317440
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
Tamsin R M Lannagan, Young K Lee, Tongtong Wang, Jatin Roper, Mark L Bettington, Lochlan Fennell, Laura Vrbanac, Lisa Jonavicius, Roshini Somashekar, Krystyna Gieniec, Miao Yang, Jia Q Ng, Nobumi Suzuki, Mari Ichinose, Josephine A Wright, Hiroki Kobayashi, Tracey L Putoczki, Yoku Hayakawa, Simon J Leedham, Helen E Abud, Ömer H Yilmaz, Julie Marker, Sonja Klebe, Pratyaksha Wirapati, Siddhartha Mukherjee, Sabine Tejpar, Barbara A Leggett, Vicki L J Whitehall, Daniel L Worthley, Susan L Woods

Gut Apr 2019, 68 (4) 684-692; DOI: 10.1136/gutjnl-2017-315920
c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis
Victor J Sánchez-Arévalo Lobo, Luis César Fernández, Enrique Carrillo-de-Santa-Pau, Laia Richart, Isidoro Cobo, Jaroslaw Cendrowski, Ulisses Moreno, Natalia del Pozo, Diego Megías, Bernardette Bréant, Christopher V Wright, Mark Magnuson, Francisco X Real

Gut Apr 2018, 67 (4) 707-718; DOI: 10.1136/gutjnl-2016-312306
Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility
Erik S Knudsen, Uthra Balaji, Brian Mannakee, Paris Vail, Cody Eslinger, Christopher Moxom, John Mansour, Agnieszka K Witkiewicz

Gut Mar 2018, 67 (3) 508-520; DOI: 10.1136/gutjnl-2016-313133

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