Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

Gastroenterology. 2014 Sep;147(3):599-601.e1. doi: 10.1053/j.gastro.2014.05.010. Epub 2014 May 21.

Abstract

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.

Keywords: Cirrhosis; Liver Disease; Transmission.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Coinfection*
  • Drug Resistance, Viral / genetics*
  • Genotype
  • HIV Infections / complications
  • HIV Infections / diagnosis
  • HIV Infections / virology*
  • HIV-1 / isolation & purification*
  • Hepacivirus / drug effects
  • Hepacivirus / genetics*
  • Hepacivirus / isolation & purification
  • Hepatitis C / complications
  • Hepatitis C / diagnosis
  • Hepatitis C / drug therapy
  • Hepatitis C / transmission*
  • Homosexuality, Male*
  • Humans
  • Male
  • Phenotype
  • Protease Inhibitors / therapeutic use*
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Unsafe Sex
  • Viral Load
  • Viral Nonstructural Proteins / antagonists & inhibitors
  • Viral Nonstructural Proteins / genetics

Substances

  • Antiviral Agents
  • NS3 protein, hepatitis C virus
  • Protease Inhibitors
  • Viral Nonstructural Proteins