Abstract
There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.
Keywords:
Cirrhosis; Liver Disease; Transmission.
Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / therapeutic use*
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Coinfection*
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Drug Resistance, Viral / genetics*
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Genotype
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HIV Infections / complications
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HIV Infections / diagnosis
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HIV Infections / virology*
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HIV-1 / isolation & purification*
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Hepacivirus / drug effects
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Hepacivirus / genetics*
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Hepacivirus / isolation & purification
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Hepatitis C / complications
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Hepatitis C / diagnosis
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Hepatitis C / drug therapy
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Hepatitis C / transmission*
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Homosexuality, Male*
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Humans
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Male
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Phenotype
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Protease Inhibitors / therapeutic use*
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Risk Factors
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Time Factors
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Treatment Outcome
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Unsafe Sex
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Viral Load
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Viral Nonstructural Proteins / antagonists & inhibitors
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Viral Nonstructural Proteins / genetics
Substances
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Antiviral Agents
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NS3 protein, hepatitis C virus
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Protease Inhibitors
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Viral Nonstructural Proteins