Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage

P V Sivakumar; G M Westrich; S Kanaly; K Garka; T L Born; J M J Derry; J L Viney

doi:10.1136/gut.50.6.812

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Inflammation and inflammatory bowel disease

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage

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	Abstract	Full	Pdf
May 2002	75	206	92
Jun 2002	56	170	79
Jul 2002	8	85	73
Aug 2002	2	66	43
Sep 2002	5	51	21
Oct 2002	4	50	38
Nov 2002	2	42	14
Dec 2002	3	18	4
Jan 2003	10	51	23
Feb 2003	2	31	18
Mar 2003	0	34	6
Apr 2003	11	39	22
May 2003	8	27	16
Jun 2003	6	24	12
Jul 2003	19	51	11
Aug 2003	15	41	12
Sep 2003	20	34	13
Oct 2003	38	66	16
Nov 2003	22	26	17
Dec 2003	27	18	9
Jan 2004	25	31	12
Feb 2004	18	22	10
Mar 2004	19	23	11
Apr 2004	22	32	20
May 2004	47	45	14
Jun 2004	55	54	27
Jul 2004	45	71	17
Aug 2004	17	34	16
Sep 2004	24	79	31
Oct 2004	19	64	23
Nov 2004	66	58	25
Dec 2004	13	41	23
Jan 2005	13	55	20
Feb 2005	13	59	46
Mar 2005	11	48	48
Apr 2005	5	31	21
May 2005	6	35	17
Jun 2005	3	27	23
Jul 2005	11	34	34
Aug 2005	8	31	18
Sep 2005	14	36	19
Oct 2005	11	52	31
Nov 2005	11	34	25
Dec 2005	7	29	23
Jan 2006	14	28	16
Feb 2006	14	28	15
Mar 2006	11	31	25
Apr 2006	12	34	11
May 2006	11	22	13
Jun 2006	8	25	14
Jul 2006	6	19	11
Aug 2006	2	15	10
Sep 2006	15	47	26
Oct 2006	14	36	18
Nov 2006	6	34	17
Dec 2006	4	19	11
Jan 2007	5	19	10
Feb 2007	9	17	11
Mar 2007	12	27	16
Apr 2007	14	11	10
May 2007	7	10	7
Jun 2007	7	3	4
Jul 2007	10	12	4
Aug 2007	8	5	3
Sep 2007	12	17	13
Oct 2007	18	7	5
Nov 2007	8	13	4
Dec 2007	6	8	6
Jan 2008	10	4	10
Feb 2008	18	11	12
Mar 2008	27	13	11
Apr 2008	27	7	5
May 2008	22	8	6
Jun 2008	11	3	2
Jul 2008	34	4	8
Aug 2008	50	7	5
Sep 2008	32	4	3
Oct 2008	21	2	4
Nov 2008	41	2	3
Dec 2008	10	14	8
Jan 2009	14	1	3
Feb 2009	12	6	7
Mar 2009	75	10	9
Apr 2009	24	6	7
May 2009	28	5	7
Jun 2009	29	8	6
Jul 2009	21	27	2
Aug 2009	13	0	3
Sep 2009	25	2	3
Oct 2009	84	6	4
Nov 2009	27	3	2
Dec 2009	15	0	3
Jan 2010	16	3	5
Feb 2010	31	6	8
Mar 2010	51	7	5
Apr 2010	28	3	4
May 2010	35	11	4
Jun 2010	14	7	7
Jul 2010	7	3	7
Aug 2010	11	6	9
Sep 2010	13	4	2
Oct 2010	13	8	1
Nov 2010	27	7	4
Dec 2010	9	4	4
Jan 2011	12	5	7
Feb 2011	22	4	6
Mar 2011	22	22	10
Apr 2011	19	7	11
May 2011	18	9	3
Jun 2011	13	7	6
Jul 2011	18	7	2
Aug 2011	18	6	1
Sep 2011	13	6	5
Oct 2011	22	6	8
Nov 2011	24	14	8
Dec 2011	25	28	9
Jan 2012	26	24	9
Feb 2012	21	22	11
Mar 2012	17	24	10
Apr 2012	13	19	14
May 2012	23	9	19
Jun 2012	16	14	14
Jul 2012	14	13	13
Aug 2012	21	10	15
Sep 2012	27	7	21
Oct 2012	20	15	12
Nov 2012	25	15	13
Dec 2012	30	8	9
Jan 2013	24	14	19
Feb 2013	42	17	11
Mar 2013	32	9	26
Apr 2013	27	14	25
May 2013	16	5	19
Jun 2013	16	8	11
Jul 2013	19	13	18
Aug 2013	16	1	12
Sep 2013	21	4	10
Oct 2013	15	14	15
Nov 2013	17	6	20
Dec 2013	33	14	25
Jan 2014	27	15	18
Feb 2014	16	2	15
Mar 2014	28	14	12
Apr 2014	26	15	12
May 2014	10	14	11
Jun 2014	30	15	13
Jul 2014	18	10	8
Aug 2014	12	11	8
Sep 2014	15	12	10
Oct 2014	14	17	11
Nov 2014	12	16	11
Dec 2014	11	11	8
Jan 2015	12	13	7
Feb 2015	13	5	8
Mar 2015	18	10	4
Apr 2015	10	11	8
May 2015	10	10	5
Jun 2015	11	12	7
Jul 2015	19	15	10
Aug 2015	13	6	2
Sep 2015	30	15	15
Oct 2015	9	2	8
Nov 2015	14	10	10
Dec 2015	17	4	12
Jan 2016	40	6	15
Feb 2016	19	6	12
Mar 2016	15	8	15
Apr 2016	19	11	16
May 2016	3	11	11
Jun 2016	10	13	14
Jul 2016	7	4	10
Aug 2016	8	6	11
Sep 2016	21	9	24
Oct 2016	24	11	13
Nov 2016	17	9	21
Dec 2016	9	6	10
Jan 2017	35	8	18
Feb 2017	4	3	8
Mar 2017	2	2	9
Apr 2017	3	16	7
May 2017	4	15	25
Jun 2017	5	16	23
Jul 2017	16	13	22
Aug 2017	24	24	13
Sep 2017	43	27	36
Oct 2017	39	35	24
Nov 2017	30	30	24
Dec 2017	23	13	12
Jan 2018	25	17	13
Feb 2018	22	14	18
Mar 2018	21	17	24
Apr 2018	9	9	13
May 2018	25	22	22
Jun 2018	15	15	18
Jul 2018	17	13	20
Aug 2018	18	14	27
Sep 2018	56	52	23
Oct 2018	133	125	22
Nov 2018	82	78	24
Dec 2018	63	63	22
Jan 2019	66	64	17
Feb 2019	53	47	21
Mar 2019	30	25	34
Apr 2019	12	6	23
May 2019	20	16	26
Jun 2019	23	17	32
Jul 2019	17	16	23
Aug 2019	13	7	21
Sep 2019	27	26	15
Oct 2019	35	31	13
Nov 2019	32	23	12
Dec 2019	45	39	18
Jan 2020	38	29	9
Feb 2020	37	35	17
Mar 2020	44	43	17
Apr 2020	35	35	14
May 2020	29	25	11
Jun 2020	30	24	8
Jul 2020	52	46	7
Aug 2020	30	30	11
Sep 2020	60	54	8
Oct 2020	46	38	16
Nov 2020	46	39	13
Dec 2020	65	61	19
Jan 2021	59	50	26
Feb 2021	70	68	12
Mar 2021	54	50	11
Apr 2021	103	83	23
May 2021	59	51	23
Jun 2021	34	34	9
Jul 2021	51	51	18
Aug 2021	46	47	23
Sep 2021	52	52	14
Oct 2021	34	34	28
Nov 2021	64	60	37
Dec 2021	54	53	14
Jan 2022	48	36	11
Feb 2022	25	23	11
Mar 2022	61	61	20
Apr 2022	51	47	13
May 2022	78	72	29
Jun 2022	68	61	20
Jul 2022	42	44	12
Aug 2022	55	57	14
Sep 2022	57	59	22
Oct 2022	63	60	18
Nov 2022	66	62	10
Dec 2022	64	60	14
Jan 2023	54	56	16
Feb 2023	79	75	10
Mar 2023	77	68	14
Apr 2023	57	45	16
May 2023	34	33	9
Jun 2023	46	33	12
Jul 2023	48	42	21
Aug 2023	49	48	20
Sep 2023	57	46	22
Oct 2023	57	45	24
Nov 2023	87	59	15
Dec 2023	120	20	6
Jan 2024	104	2	1
Feb 2024	94	1	3
Mar 2024	122	5	3
Total	7360	6919	3914

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