We thank Saito et al for their interest in our paper that prospectively examined the safety and efficacy of high magnification chromoscopic colonoscopy for the diagnosis of neoplasia in flat and depressed lesions of the colorectum (Gut 2004;53:284–90).

Their abstract data,¹ using the modified Paris classification of superficial neoplastic lesions,² as determined by the newly designated 1000m vertical mucosal extension limit, offers impressive sensitivity and overall accuracy rates when distinguishing sm1 from sm2 …