Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

Annabelle Lewis; Stefania Segditsas; Maesha Deheragoda; Patrick Pollard; Rosemary Jeffery; Emma Nye; Helen Lockstone; Hayley Davis; Susan Clark; Gordon Stamp; Richard Poulsom; Nicholas Wright; Ian Tomlinson

doi:10.1136/gut.2009.193680

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Colon cancer

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Severe polyposis in Apc^1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

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	Abstract	Full	Pdf
Oct 2010	262	107	146
Nov 2010	297	164	221
Dec 2010	71	174	167
Jan 2011	31	68	58
Feb 2011	27	95	55
Mar 2011	42	83	51
Apr 2011	19	54	48
May 2011	19	31	30
Jun 2011	27	42	42
Jul 2011	28	34	35
Aug 2011	29	18	25
Sep 2011	31	28	32
Oct 2011	49	50	26
Nov 2011	71	45	22
Dec 2011	57	23	15
Jan 2012	53	63	28
Feb 2012	45	33	19
Mar 2012	57	22	27
Apr 2012	48	27	15
May 2012	45	34	32
Jun 2012	44	26	24
Jul 2012	33	37	24
Aug 2012	37	20	18
Sep 2012	38	13	13
Oct 2012	20	18	25
Nov 2012	55	13	21
Dec 2012	48	16	10
Jan 2013	42	21	12
Feb 2013	62	36	20
Mar 2013	48	35	24
Apr 2013	44	21	23
May 2013	41	20	19
Jun 2013	32	14	14
Jul 2013	16	8	10
Aug 2013	37	6	7
Sep 2013	19	10	13
Oct 2013	37	12	7
Nov 2013	43	14	14
Dec 2013	49	16	19
Jan 2014	30	21	12
Feb 2014	23	6	6
Mar 2014	28	11	16
Apr 2014	23	18	14
May 2014	24	12	6
Jun 2014	29	18	11
Jul 2014	32	24	8
Aug 2014	23	17	11
Sep 2014	29	6	14
Oct 2014	32	17	20
Nov 2014	20	10	7
Dec 2014	33	23	11
Jan 2015	18	18	16
Feb 2015	35	3	15
Mar 2015	32	11	9
Apr 2015	15	6	6
May 2015	16	9	6
Jun 2015	22	10	15
Jul 2015	19	6	7
Aug 2015	18	2	15
Sep 2015	57	11	29
Oct 2015	7	5	8
Nov 2015	6	2	7
Dec 2015	35	12	8
Jan 2016	16	11	12
Feb 2016	15	11	8
Mar 2016	15	6	20
Apr 2016	28	9	10
May 2016	10	9	19
Jun 2016	20	7	4
Jul 2016	38	15	21
Aug 2016	19	14	4
Sep 2016	35	17	10
Oct 2016	27	13	17
Nov 2016	40	8	11
Dec 2016	20	16	10
Jan 2017	22	10	5
Feb 2017	5	8	10
Mar 2017	1	18	5
Apr 2017	7	28	4
May 2017	2	23	5
Jun 2017	5	22	9
Jul 2017	13	12	6
Aug 2017	31	20	6
Sep 2017	23	15	2
Oct 2017	19	17	9
Nov 2017	36	24	1
Dec 2017	15	15	7
Jan 2018	25	23	28
Feb 2018	31	29	11
Mar 2018	31	25	9
Apr 2018	30	29	2
May 2018	21	15	3
Jun 2018	36	32	6
Jul 2018	40	33	3
Aug 2018	11	11	1
Sep 2018	28	28	14
Oct 2018	24	24	4
Nov 2018	13	13	8
Dec 2018	12	10	8
Jan 2019	11	11	7
Feb 2019	11	10	4
Mar 2019	18	16	14
Apr 2019	14	13	5
May 2019	16	12	10
Jun 2019	12	12	6
Jul 2019	16	11	17
Aug 2019	37	33	8
Sep 2019	22	22	6
Oct 2019	17	11	2
Nov 2019	19	16	12
Dec 2019	13	11	9
Jan 2020	17	17	6
Feb 2020	9	9	12
Mar 2020	24	25	20
Apr 2020	15	15	3
May 2020	6	6	3
Jun 2020	12	10	4
Jul 2020	16	10	13
Aug 2020	7	6	4
Sep 2020	28	23	3
Oct 2020	19	17	8
Nov 2020	30	14	15
Dec 2020	27	21	9
Jan 2021	14	10	13
Feb 2021	7	7	7
Mar 2021	23	18	12
Apr 2021	19	11	6
May 2021	9	9	4
Jun 2021	13	13	7
Jul 2021	13	13	4
Aug 2021	8	5	5
Sep 2021	19	19	6
Oct 2021	11	11	21
Nov 2021	20	18	19
Dec 2021	23	23	5
Jan 2022	23	23	11
Feb 2022	17	21	2
Mar 2022	21	17	11
Apr 2022	18	16	9
May 2022	36	32	14
Jun 2022	22	22	6
Jul 2022	20	16	4
Aug 2022	38	34	8
Sep 2022	27	25	25
Oct 2022	24	24	8
Nov 2022	18	15	9
Dec 2022	26	20	5
Jan 2023	24	22	10
Feb 2023	41	40	5
Mar 2023	13	11	1
Apr 2023	8	9	6
May 2023	10	6	11
Jun 2023	11	7	2
Jul 2023	13	12	10
Aug 2023	13	11	7
Sep 2023	14	14	6
Oct 2023	19	18	4
Nov 2023	29	19	3
Dec 2023	28	28	6
Jan 2024	37	37	11
Feb 2024	27	25	23
Mar 2024	24	21	12
Total	4619	3502	2538

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