Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

Wei Huang; David M Booth; Matthew C Cane; Michael Chvanov; Muhammad A Javed; Victoria L Elliott; Jane A Armstrong; Hayley Dingsdale; Nicole Cash; Yan Li; William Greenhalf; Rajarshi Mukherjee; Bhupendra S Kaphalia; Mohammed Jaffar; Ole H Petersen; Alexei V Tepikin; Robert Sutton; David N Criddle

doi:10.1136/gutjnl-2012-304058

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Pancreas

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Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca²⁺-dependent mitochondrial dysfunction and acute pancreatitis

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Oct 2013	217	131	72
Nov 2013	554	168	166
Dec 2013	306	68	48
Jan 2014	147	60	44
Feb 2014	43	63	57
Mar 2014	51	89	40
Apr 2014	48	56	40
May 2014	36	42	347
Jun 2014	41	28	18
Jul 2014	1001	76	147
Aug 2014	414	59	64
Sep 2014	248	82	52
Oct 2014	177	135	79
Nov 2014	125	40	32
Dec 2014	103	56	59
Jan 2015	102	35	378
Feb 2015	58	20	4592
Mar 2015	199	76	117
Apr 2015	63	49	44
May 2015	46	34	26
Jun 2015	32	28	61
Jul 2015	42	34	35
Aug 2015	21	28	32
Sep 2015	57	23	31
Oct 2015	35	18	36
Nov 2015	29	19	42
Dec 2015	49	33	39
Jan 2016	36	10	5
Feb 2016	27	15	15
Mar 2016	35	17	25
Apr 2016	34	23	31
May 2016	50	17	28
Jun 2016	37	21	39
Jul 2016	57	34	35
Aug 2016	32	16	16
Sep 2016	67	36	25
Oct 2016	44	24	90
Nov 2016	47	19	20
Dec 2016	37	26	30
Jan 2017	85	27	17
Feb 2017	29	16	27
Mar 2017	5	34	19
Apr 2017	8	52	23
May 2017	9	60	43
Jun 2017	9	28	20
Jul 2017	33	30	27
Aug 2017	42	38	17
Sep 2017	58	40	35
Oct 2017	46	38	17
Nov 2017	45	31	13
Dec 2017	40	32	14
Jan 2018	55	53	15
Feb 2018	67	53	18
Mar 2018	83	61	31
Apr 2018	55	51	18
May 2018	59	55	22
Jun 2018	67	56	14
Jul 2018	56	50	14
Aug 2018	35	33	12
Sep 2018	27	23	17
Oct 2018	38	26	25
Nov 2018	50	34	20
Dec 2018	35	33	26
Jan 2019	34	30	17
Feb 2019	46	41	31
Mar 2019	58	46	32
Apr 2019	37	37	36
May 2019	44	30	106
Jun 2019	46	42	17
Jul 2019	53	38	42
Aug 2019	53	39	37
Sep 2019	49	41	26
Oct 2019	98	56	23
Nov 2019	64	50	36
Dec 2019	55	51	30
Jan 2020	63	56	18
Feb 2020	46	33	22
Mar 2020	47	42	24
Apr 2020	35	27	15
May 2020	36	32	21
Jun 2020	33	29	26
Jul 2020	40	37	34
Aug 2020	44	39	40
Sep 2020	69	63	53
Oct 2020	44	39	27
Nov 2020	45	43	42
Dec 2020	72	69	40
Jan 2021	60	49	49
Feb 2021	55	46	31
Mar 2021	69	59	23
Apr 2021	49	37	15
May 2021	91	86	33
Jun 2021	43	38	21
Jul 2021	40	36	32
Aug 2021	45	44	33
Sep 2021	44	44	23
Oct 2021	49	48	28
Nov 2021	43	36	40
Dec 2021	53	49	42
Jan 2022	105	78	69
Feb 2022	47	42	28
Mar 2022	63	59	43
Apr 2022	81	78	32
May 2022	79	76	42
Jun 2022	69	62	35
Jul 2022	71	45	12
Aug 2022	99	83	31
Sep 2022	92	90	28
Oct 2022	90	78	30
Nov 2022	97	86	40
Dec 2022	85	82	34
Jan 2023	85	83	34
Feb 2023	69	63	31
Mar 2023	109	89	44
Apr 2023	58	51	23
May 2023	88	74	37
Jun 2023	61	50	20
Jul 2023	101	90	37
Aug 2023	63	41	14
Sep 2023	47	45	5
Oct 2023	97	86	34
Nov 2023	143	97	20
Dec 2023	153	137	51
Jan 2024	86	86	136
Feb 2024	97	86	57
Mar 2024	92	84	118
Total	9962	6365	9811

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