A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS

Dan Rosmarin; Claire Palles; Alistair Pagnamenta; Kulvinder Kaur; Guillermo Pita; Miguel Martin; Enric Domingo; Angela Jones; Kimberley Howarth; Luke Freeman-Mills; Elaine Johnstone; Haitao Wang; Sharon Love; Claire Scudder; Patrick Julier; Ceres Fernández-Rozadilla; Clara Ruiz-Ponte; Angel Carracedo; Sergi Castellvi-Bel; Antoni Castells; Anna Gonzalez-Neira; Jenny Taylor; Rachel Kerr; David Kerr; Ian Tomlinson

doi:10.1136/gutjnl-2013-306571

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A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS

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Mar 2014	327	180	133
Apr 2014	275	221	90
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Jun 2014	89	88	52
Jul 2014	68	78	50
Aug 2014	48	69	31
Sep 2014	50	53	67
Oct 2014	59	41	38
Nov 2014	36	77	27
Dec 2014	1002	82	117
Jan 2015	620	59	202
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Mar 2015	263	57	70
Apr 2015	155	45	46
May 2015	154	34	20
Jun 2015	136	46	40
Jul 2015	113	22	14
Aug 2015	132	46	35
Sep 2015	124	54	26
Oct 2015	64	20	19
Nov 2015	103	35	14
Dec 2015	125	47	23
Jan 2016	103	43	23
Feb 2016	74	22	16
Mar 2016	56	26	27
Apr 2016	40	16	17
May 2016	69	34	24
Jun 2016	67	33	24
Jul 2016	59	28	24
Aug 2016	45	23	16
Sep 2016	62	25	19
Oct 2016	55	21	15
Nov 2016	52	40	14
Dec 2016	32	22	7
Jan 2017	44	44	20
Feb 2017	13	27	22
Mar 2017	3	34	29
Apr 2017	6	66	16
May 2017	7	55	22
Jun 2017	14	40	15
Jul 2017	40	35	22
Aug 2017	54	44	13
Sep 2017	49	32	15
Oct 2017	43	30	11
Nov 2017	67	57	17
Dec 2017	65	51	20
Jan 2018	66	56	21
Feb 2018	47	41	12
Mar 2018	66	53	20
Apr 2018	65	55	17
May 2018	76	68	16
Jun 2018	67	55	16
Jul 2018	84	82	8
Aug 2018	79	69	7
Sep 2018	81	73	10
Oct 2018	97	93	16
Nov 2018	137	119	15
Dec 2018	79	75	17
Jan 2019	87	83	15
Feb 2019	78	70	27
Mar 2019	48	48	25
Apr 2019	56	48	42
May 2019	72	49	37
Jun 2019	41	39	28
Jul 2019	36	36	33
Aug 2019	59	37	24
Sep 2019	42	23	13
Oct 2019	43	31	17
Nov 2019	60	38	24
Dec 2019	60	54	25
Jan 2020	47	42	10
Feb 2020	52	40	21
Mar 2020	42	37	24
Apr 2020	55	35	91
May 2020	52	45	50
Jun 2020	25	19	19
Jul 2020	37	30	25
Aug 2020	36	19	17
Sep 2020	52	42	21
Oct 2020	58	46	22
Nov 2020	48	32	20
Dec 2020	41	39	26
Jan 2021	44	35	22
Feb 2021	32	24	13
Mar 2021	44	36	27
Apr 2021	37	24	17
May 2021	32	31	13
Jun 2021	36	36	17
Jul 2021	43	43	15
Aug 2021	58	55	19
Sep 2021	28	28	19
Oct 2021	31	23	36
Nov 2021	45	30	37
Dec 2021	48	38	10
Jan 2022	40	20	25
Feb 2022	45	34	21
Mar 2022	26	22	20
Apr 2022	69	59	23
May 2022	64	52	33
Jun 2022	49	36	14
Jul 2022	32	19	7
Aug 2022	39	29	29
Sep 2022	41	36	48
Oct 2022	60	49	23
Nov 2022	45	25	22
Dec 2022	35	32	11
Jan 2023	41	27	14
Feb 2023	42	37	17
Mar 2023	58	39	16
Apr 2023	42	16	18
May 2023	36	25	18
Jun 2023	34	21	18
Jul 2023	34	22	19
Aug 2023	26	24	10
Sep 2023	59	34	19
Oct 2023	36	32	23
Nov 2023	32	32	18
Dec 2023	66	50	41
Jan 2024	27	25	33
Feb 2024	38	34	24
Mar 2024	36	26	71
Total	9327	5459	3425

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